At Startup Boston Week 2025, one of the most candid conversations of the week didn’t focus on fundraising tactics or growth hacks. Instead, it tackled something founders often discuss far less publicly: burnout, bias, resilience, and the support systems required to keep building. The session Real Talk from the Trenches: Female Founders on Tradeoffs, Grit and Support Systems brought together moderator Sheri Palazzo (Founder, Saplings Consulting) alongside Erin Dewicki (CEO, Ly

42% of SaaS startups fail because there's no market need. Another 14% fail from weak positioning. Everyone treats these as separate problems. They're not. The root cause is the same: a broken answer to one question. Who is this for, and why does it matter? That's positioning. When positioning is unclear, everything breaks downstream. Sales pursues deals that were never a fit. Messaging bounces off because it doesn't reshape what buyers already believe. Pricing feels arbitrary

It was a cold Saturday morning in Connecticut. I was playing the second round of a Level 4 tournament - one of those matches where nothing was working. I was losing points I should be winning easily. My return game was breaking down. Double faults at the worst moments. I had a sense something was off, but no way to pinpoint what. My coach wasn't there. No one was tracking point by point. After my loss and during the long car ride back, I found myself trying to piece together

While Botox gets most of the attention in our modern culture of dermal aesthetic procedures, filler injections are incredibly common as well. There are an estimated 7.8 million filler injections performed annually, according to a 2024 report by the American Society of Plastic Surgeons. What many don’t realize is that patients are at risk of blindness or a stroke if a blood vessel is poked while giving the injection. It’s enough to keep any aesthetic injector up at night. Kare

Being a successful founder is rewarding and challenging. Now imagine taking on this role and responsibility again. Joanna Shu did just that. She’s the co-founder and CEO of Cartwheel Health , a medical device startup developing an innovative, non-toxic treatment for head lice. In this conversation with Startup Boston, Shu discusses why creating Cartwheel Health was personal for her, how humor is important in their branding, lessons learned from her first startup, and more.

At Startup Boston Week, Christina Luconi (People Innovator, People Innovations) delivered a clear message founders often overlook: startups do not fail because they ignore culture, instead, they fail because they assume culture can wait. For many early-stage companies, survival mode takes over. Founders are chasing product-market fit, fundraising, hiring, customer growth, and solving a dozen urgent problems before lunch. In that environment, culture can feel like a luxury it

Despite recent price pressure, crypto continues to gain adoption as the technology moves deeper into mainstream finance and market infrastructure. That shift is central to the thesis behind tmr Ventures, an early-stage venture firm based in Boston and founded by Lucas He to back crypto companies building practical, durable businesses at the intersection of blockchain and capital markets. He brings more than a decade of experience in blockchain, dating back to 2012, along wit

At Startup Boston Week, Nathan Johnson (CEO, Verne Bio), Piyali Chakraborty (CEO & Cofounder, Ashmi Health), Pradeep Bokinala (CTO, Simbex), Jane Allard (Director of Governance Engineering, GSK) and Ashley Mae Conard (Senior Researcher, Microsoft) tackled one of the most complex challenges in modern innovation: how to build and scale software in life sciences - where messy data, strict regulations, and real human impact collide. If there was one theme that emerged again

April is kicking off strong in Boston’s startup ecosystem, with a packed calendar of events bringing together founders, operators, investors, students, and ecosystem builders. From AI summits and robotics showcases to founder-focused panels, demo days, and cross-university mixers, this month is all about momentum, collaboration, and building what’s next. Startup Boston is helping anchor the month with a series of community-powered experiences. Here are four to have on your ra

If you've been building a company in Boston for any amount of time, you've had the meeting. Things are going fine, the investor seems interested, and then somewhere in the middle of it they ask if you've thought about relocating. Not because anything is wrong with the business. Just because you're in Boston and not somewhere else. And now instead of talking about your company you're spending ten minutes explaining why Boston is actually a legitimate place to build things, whi

Boston doesn’t just show up in biotech rankings, it rewrites what biotech even looks like. This is a city where AI is designing drugs, biology is becoming programmable, and labs are starting to look a lot more like software companies. And while the usual names get the spotlight, there’s a new wave of startups building just as aggressively - faster experiments, smarter platforms, and entirely new ways to bring medicine to life. Below are the Boston biotech startups to watch ri

Building a startup takes more than a great idea. Founders are constantly navigating decisions across finance, hiring, legal, marketing, product development, banking, and infrastructure, often all at once. And while Boston and New England are home to an incredible network of resources, knowing where to start (and who to trust) can be half the battle. That’s exactly why we created The Startup Directory : a curated list of organizations that actively support founders building an

On a snowy Boston morning, founders, legal experts, and ecosystem leaders gathered for a conversation that tackled a reality many entrepreneurs face but few openly discuss: building a startup while navigating immigration status. Hosted by Startup Boston in partnership with the City of Boston, the session we learned from Deepanshi Bansal (Founder, ShineQuo), Jashin Lin (Founder, Growbie), Allison Ahern Fillo (Immigrant Counsel, Davis Malm) and Anushka Singh (Founder, Katha

March brings a calendar full of opportunities to bring founders, operators, investors, students, and ecosystem builders together in Boston’s startup ecosystem. From intimate founder dinners and mentorship moments to high-energy networking mixers, resource expos, and campus-wide innovation meetups, this month is all about connection, learning, and momentum. Startup Boston is helping anchor the month with a series of community-powered experiences. Here are four to have on your

Building a startup isn’t just about product, funding, or growth metrics: it’s about people. As companies move from scrappy early teams to scaling organizations, the real challenges shift. Foundership becomes leadership. Culture must be intentional, not accidental. Hiring, performance, and team health become strategic priorities rather than operational afterthoughts. This evolution is where many startups struggle and where the strongest companies differentiate themselves. The

Boston doesn’t have a startup “season,” it has an ecosystem calendar. From student-led venture summits in the spring to climate, robotics, AI, fintech, and deep-tech gatherings throughout the year, New England hosts a steady rhythm of events that bring builders, investors, researchers, operators, and ecosystem leaders into the same rooms and onto the same ideas. These moments matter. They spark partnerships, unlock funding pathways, surface new talent, and help founders find

Startup funding conversations tend to follow a familiar script: raise a seed round, close Series A and scale toward Series B. Equity dominates the narrative. But as companies mature and markets evolve founders face a more complex question: what comes next? At Startup Boston Week, Janice Bourque (Hercules Capital), Matthew Ahern (Knightsbridge Advisers), Will Kidston (Kenston Capital Partners), Yeng Felipe Butler (Chestnut Run Capital Partners) and Will Bernat (Nutter) un

When people hear “tech,” they often think of AI, software, or robotics. Food rarely makes the list. But at Startup Boston Week, a panel of founders, scientists, and sustainability experts made it clear: the future of food may be one of the most important technological frontiers of our time. From cultivated meat and regenerative agriculture to pest monitoring and sustainable supply chains, the conversation with Oliver Sanchez (Extrasense), Nicky Roberts (Sustainability Consu

Performance management rarely makes the “top reasons I started a company” list. Yet at Startup Boston Week, a packed room of founders, operators, and people leaders stayed late for a candid conversation about one of the most overlooked levers of startup success: how teams give feedback, set expectations, and help people grow. Moderated by former Chief People Officer Christina Luconi (People Innovations), the panel featured talent and HR leaders Tania Philipp (Vor Bio), Laur

Last week, Startup Boston teamed up with the City of Boston to host Meet Boston’s Startup Networking Groups , bringing together founders, operators, students and ecosystem builders for one simple purpose: helping people find their place in the startup community. The room filled quickly with over 200 attendees connecting directly with communities that make Boston’s startup ecosystem feel accessible, welcoming and collaborative. Because here’s the truth: Boston’s startup scene